Automation
Laboratory Instrumentation

Laboratory Instrumentation White Papers

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136-150 of 242 results
Ensuring Accurate and Repeatable Measurement of Proteins Using the Zetasizer APS
| By Malvern Panalytical
In this application note, well known protein samples were used in a crosscontamination test to investigate the accuracy and repeatability of the Zetasizer APS dynamic light scattering (DLS) system.
Automation > Laboratory Instrumentation > White Papers
Effect of Excipients on Protein Formulation Viscosity
| By Malvern Panalytical
In the development of injectable biotherapeutics, drug efficacy and patient experience are both very important parameters. In order to maximize activity and efficacy, biotherapeutics are usually delivered intravenously or subcutaneously in high concentrations, typically >100g/mL, due to their short half-life in plasma.
Automation > Laboratory Instrumentation > White Papers
Reverse Engineering of a Pharmaceutical Formulation Using the Morphologi G3-ID
| By Malvern Panalytical
According to the definition established by the FDA, a generic drug is "a drug product which is comparable to a reference listed drug (RLD) product in dosage form, strength, route of administration, quality, performance characteristics, and intended use". Rigorous rules and regulations pertaining to abbreviated new drug application (ANDA) submissions are complex and the generic drug industry strives to meet these regulations to obtain FDA's approval.
Automation > Laboratory Instrumentation > White Papers
Molecular Weight Measurements of an Antibody Using Viscotek SEC-MALS 20
| By Malvern Panalytical
Therapeutic recombinant antibodies, primarily of the Immunoglobulin G isotype (IgG), represent a growing proportion of biopharmaceuticals. There are an ever increasing number of approved antibody therapies available to treat a variety of modern-day diseases such as cancer, rheumatoid arthritis and diabetes. With many more candidate IgG's in the biopharmaceutical development pipeline the pressure to accurately understand and develop these candidates becomes more and more important.
Automation > Laboratory Instrumentation > White Papers
The use of ITC for Obtaining Enzyme Kinetic Constants
| By Malvern Panalytical
Enzymes are proteins that function as biological catalysts and they play a crucial role in nearly all processes that take place in living organisms. Therefore studies of these molecules and the reactions they catalyze have been a core activity for biochemists for at least the past fifty years.
Automation > Laboratory Instrumentation > White Papers
Understanding the Conformational Stability of Protein Therapeutics using Raman Spectroscopy
| By Malvern Panalytical
The combination of Dynamic Light Scattering (DLS) with Raman Spectroscopy provides the ability to extract a wealth of chemical, structural, and physical information about biotherapeutic proteins under formulation conditions.
Automation > Laboratory Instrumentation > White Papers
Using Laser Diffraction Particle Size Data to Optimise the Performance of Sprays
| By Malvern Panalytical
Many industries share the need to closely control the characteristics of sprays, albeit for very different reasons, and one of the most critical parameters is the particle size of the droplets within the spray plume.
Automation > Laboratory Instrumentation > White Papers
Developing a Bioformulation Stability Profile
| By Malvern Panalytical
When used in combination, light scattering and microcapillary viscometry can be used to develop a stability profile to screen biotherapeutic candidates, with light scattering providing a suite of dilute solution properties and microcapillary viscometry providing analysis of viscosity even at high sample concentration.
Automation > Laboratory Instrumentation > White Papers
Real-Time Particle Sizing for Granulation Control
| By Malvern Panalytical
This paper considers various granulation processes and the use of real-time particle size measurement in their optimisation, focusing on two different sizing methods: laser diffraction and the spatial filter technique (SFT).
Automation > Laboratory Instrumentation > White Papers
Laser Diffraction and Automated Imaging: Complementary Techniques for Nasal Spray Development
| By Malvern Panalytical
Nasal spray products are increasingly valued for delivering systemic as well as locallyacting therapies, most notably hormone and migraine treatments. The large surface area and rich blood supply of the nasal passages aid the rapid absorption of drug entities, with their close proximity to the central nervous system being of particular benefit.
Automation > Laboratory Instrumentation > White Papers
Automation of QC Microscope Measurements of a Pharmaceutical Ointment Using the Morphologi Particle Characterisation System
| By Malvern Panalytical
In Quality Control (QC) procedures many pharmaceutical companies rely on microscope-based analyses to identify, qualify and or quantify solid particles meeting specified size criteria.
Automation > Laboratory Instrumentation > White Papers
Applications of Isothermal Titration Calorimetry and Differential Scanning Calorimetry in Biopharmaceutical
| By Malvern Panalytical
Development of protein-based therapeutics is a challenging task due to inherent protein instabilities, which can manifest as physical instability (unfolding, aggregation, adsorption), and chemical degradation (oxidation, deamidation, cleavage). Such instabilities can lead to reduced activity of the protein or even generation of potentially immunogenic species.
Automation > Laboratory Instrumentation > White Papers
Evaluating Product Delivery Characteristics from a Bottle, Tube or Spray Pack
| By Malvern Panalytical
Many consumer products are packaged in tubes or bottles where product application involves pumping the product through a nozzle. Such products tend to be shearthinning products where the viscosity drops during the extrusion process due to the increasing shear rate, and then recovers on exiting the nozzle as the shear rate is reduced.
Automation > Laboratory Instrumentation > White Papers
Differential Scanning Calorimetry as a Tool for Rapid and Efficient Development of Economical Biopharmaceutical Processes
| By Malvern Panalytical
Biopharmaceutical process development can be costly and time-consuming. The ultimate goal is to maximise the yield of purified product by the most costeffective, reproducible and robust route.
Automation > Laboratory Instrumentation > White Papers
Using Differential Scanning Calorimetry to Accelerate Liquid Formulation Development for Protein Biopharmaceuticals
| By Malvern Panalytical
Monoclonal antibody development projects exist for a wide variety clinical indications. Recombinant proteins of commercial interest, including monoclonal antibodies, need additional properties beyond their biological activity to enable their development into successful biopharmaceuticals.
Automation > Laboratory Instrumentation > White Papers
136-150 of 242 results