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Laboratory Instrumentation White Papers

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1-15 of 206 results
Going with the Flow: Malvern Instruments' Basic Introduction to Rheology
| By Malvern Instruments
Rheology concerns itself with materials that have aspects of both solids and liquids, and researches the flow and deformation of matter. Malvern Instruments explores this study, and reveals its fundamental in relation to force, deformation and time.
Automation > Laboratory Instrumentation > White Papers
Malvern Instruments Shares its Buyer's Guide to Protein Stability Measurement Platforms
| By Malvern Instruments
As a leader in best practices during biopharmaceutical development, Malvern Instruments sheds light on effective protein stability analysis technologies for the biopharmaceutical industry.
Automation > Laboratory Instrumentation > White Papers
Reliable, Long-range Wireless Sensors for Environmental Monitoring
| By Vaisala pbr
The Vaisala viewLinc Monitoring System tracks environmental conditions wirelessly using Vaisala’s VaiNet wireless devices based on LoRa™* technology. By using a chirp spread spectrum (CSS)* wireless protocol, VaiNet provides robust communication that is extremely reliable over long distances and under harsh, complex and obstructed conditions.
Automation > Laboratory Instrumentation > White Papers
Five Ways That the Mastersizer 3000 Saves you Money
| By Malvern Instruments
To earn its place in today’s busy analytical laboratories, an instrument must meet certain practical criteria, and stand-up to rigorous economic evaluation. For labs that need particle sizing, laser diffraction systems are typically the technology of choice; delivering accurate and reliable information for the broadest range of sample types. Here, we look at how the Mastersizer 3000, the market leading laboratory particle size analyzer from Malvern Instruments, can save you time, money and resources, and ultimately deliver a healthy return on investment.
Automation > Laboratory Instrumentation > White Papers
Time to Spec up? Top Five Reasons to Replace a Viscometer with a Rheomete
| By Malvern Instruments
Is your viscometer approaching the end of its life? Are you starting to feel that your trial and error, ‘rheology-light’ approach to formulation is becoming dated? Or are there longstanding product performance issues that you’re failing to gain traction with, where you suspect rheology may hold the answer?
Automation > Laboratory Instrumentation > White Papers
Biophysical Characterization of Epigenetic Protein Interactions
| By Malvern Instruments
Epigenetics is the study of heritable changes in gene expression caused by nongenetic mechanisms, without alterations in gene structure or DNA sequence. The epigenetic state of a cell evolves during the cellular differentiation and development of an organism, and epigenetic changes are linked to cellular reprogramming. Because epigenetic mechanisms may also be responsible for the integration of environmental responses at he cellular level, they potentially play an important role in the development of som diseases.
Automation > Laboratory Instrumentation > White Papers
Overcoming and Quantifying 'Wall Slip' in Measurements from a Rotational Rheometer
| By Malvern Instruments
When making shear rheological measurements on structured liquids, in particular suspensions, emulsions or foams there is a high probability that the measurement may be affected by a phenomenon known as 'wall slip'. Wall slip generally results from a localdepletion of the dispersed phase near the geometry walls, effectively forming a lubrication layer at the surface. As a consequence bulk rheological properties are no longer being accurately measured leading to an underestimation of the true viscosity. A similar effect can be observed when measuring solid like materials where there is insufficient friction between the sample and the wall to support the applied stress.
Automation > Laboratory Instrumentation > White Papers
Preformulation and Stability Studies of Biotherapeutics Using DSC
| By Malvern Instruments
The use of biotherapeutics, such as antibodies and other protein molecules, to treat diseases is a rapidly growing field in the pharmaceutical industry.Biotherapeutics are often required at high concentrations and multiple doses, hence a manufacturer must produce kilogram quantities or more of the protein drug. The manufacturing process for biotherapeutics involves protein expression in thousands of liters of bioreactor medium followed by a purification process using large-scale chromatography columns and filtration systems.
Automation > Laboratory Instrumentation > White Papers
Protein Storage and Stability Analysis Using the Zetasizer Nano ZSP
| By Malvern Instruments
Spidroins are a unique family of large, structural proteins that make up the bulk of spider silk fibres. The mechanical strength and elasticity of spider silk fibres have led to their successful use in the regeneration of peripheral nerves in rats [1], with the same properties giving the potential for use in a wide range of other applications [2,3,4]. The production of these proteins on an industrial scale, however, has only become possible fairly recently
Automation > Laboratory Instrumentation > White Papers
Using Differential Scanning Calorimetry to Inform and Accelerate Process Development for Protein Therapeutics
| By Malvern Instruments
The production and purification of immunoglobulins of the gamma isotype, particularly human IgG1, for diagnostic or therapeutic applications is now fairly routine. In the past decade IgE-based therapeutics have also gained momentum (1-3). IgE is important for host defense against parasites and for protective inflammation. Yet, IgE-mediated signaling through its receptors is also a focal point of inflammatory allergic disease (4). The constant region of IgE, is a homodimer containing duplicate pairs of three unique Ig-fold domains (Cε2, Cε3, and Cε4), and is responsible for binding its two receptors, FcεRI and CD23, also known as FcεRII.
Automation > Laboratory Instrumentation > White Papers
Evaluating Product Texture Using Oscillatory Testing on a Rotational Rheometer
| By Malvern Instruments
Formulating products to have both the correct functional and sensory attributes can be a difficult task. The latter in particular relies heavily on user feedback which can take considerable time and effort to attain. In addition it is not always easy to interpret such feedback in the context of material properties and hence rheological data.
Automation > Laboratory Instrumentation > White Papers
Estimating BSA Aggregation Kinetics with Dynamic Light Scattering and Raman Spectroscopy
| By Malvern Instruments
Towards a unified biophysical characterization platform: Combining dynamic light scattering and Raman spectroscopy*.
Automation > Laboratory Instrumentation > White Papers
An Introduction to DLS Microrheology
| By Malvern Instruments
Microrheology techniques involve tracking the motion of dispersed probe (or tracer) particles in a complex fluid, to extract local and bulk rheological properties of the matrix. Analogous to mechanical rheometry techniques, a stress is applied to the system by motion of the probe particle, and the deformation (or strain) is measured through changes in the probe particle position.
Automation > Laboratory Instrumentation > White Papers
1-15 of 206 results