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Laboratory Instrumentation White Papers

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1-15 of 140 results
Important Factors when Buying a Differential Scanning Calorimeter (DSC)
| By Malvern Instruments
The physical components and features of a Differential Scanning Calorimeter (DSC) instrument and the technical specifications are clearly important to consider when purchasing a new system. However, written specifications can be confusing, misleading and may actually have very little bearing on the actual performance of the instrument. Specifications, on paper, do not necessarily translate into advantages or disadvantages when it comes to making measurements on your samples.
Automation > Laboratory Instrumentation > White Papers
Understanding the Effect of Molecular Weight and Structure on the Performance Characteristics of Cellulose Derivatives using OMNISEC
| By Malvern Instruments
A key family of molecules of interest to the pharmaceutical industry is those derived from cellulose such as hydroxyethyl cellulose and others. These macromolecules are typically used as viscosity modifiers for various products such as eye drops and moisturizing creams, and as excipients in many other applications.
Automation > Laboratory Instrumentation > White Papers
Forensic Analysis of an Artificial Sweetener Commonly Employed in Hoax Powder Attacks Using Morphologically Directed Raman Spectroscopy
| By Malvern Instruments
In the wake of the September 11th terrorist attacks, there was an influx of white powder events throughout the United States. A white powder event is when an unknown white powder is received in the post. More often than not, the attacks do not contain any toxic materials and are carried out for the sole purpose of causing terror and damaging infrastructure. Since these attacks, the FBI and US Postal Service have responded to thousands of white powder events.
Automation > Laboratory Instrumentation > White Papers
Characterisation of IgG Monomers and their Aggregates
| By Malvern Instruments
Whether we are trying to improve candidate formulations or trying to characterize final formulations, knowing exactly what a protein sample comprises and how much we have of each component is of paramount importance.
Automation > Laboratory Instrumentation > White Papers
Evaluating the Rheological Properties of Hyaluronic Acid Hydrogels for Dermal Filler Applications
| By Malvern Instruments
Hyaluronic acid (HA) is a naturally occurring polysaccharide frequently used as a functional ingredient in many topical and subcutaneous anti-ageing treatments such as dermal fillers, which exploit the polymer’s unique viscoelastic properties for effective soft tissue augmentation. When administered subcutaneously, HA builds an elastic network within wrinkles and rhytides to give the skin a plumper and fuller look.
Automation > Laboratory Instrumentation > White Papers
Characterisation of Pollen Samples with the Morphologi® G3SE
| By Malvern Instruments
Some of the most frequent inhalant allergens from the natural environment are present in pollen grains and a wide range of pollen source material is used in the production of immunotherapy or diagnostic products as well as in allergy research.
Automation > Laboratory Instrumentation > White Papers
An Introduction to OMNISEC REVEAL
| By Malvern Instruments
This technical note describes the system and explains how OMNISEC sets a new standard in molecular characterization.
Automation > Laboratory Instrumentation > White Papers
An Introduction to OMNISEC RESOLVE
| By Malvern Instruments
This technical note describes the features and benefits of OMNISEC RESOLVE. It also includes a discussion of the value of OMNISEC as a complete system as opposed to upgrading an existing conventional system to advanced detection.
Automation > Laboratory Instrumentation > White Papers
The Mark–Houwink plot – Differentiation of Branching and Composition
| By Malvern Instruments
In this application note, we will show how to separate the effects of a structural difference induced by a compositional change to a polymer (e.g. substitution) and the structural change induced by polymer chain branching.
Automation > Laboratory Instrumentation > White Papers
GPC/SEC Analysis of Polylactic Acid (PLA) and Poly(lactic-co-glycolic acid) (PLGA) Using OMNISEC
| By Malvern Instruments
In this application note, a selection of different PLA and PLGA polymer samples were analyzed on Malvern's OMNISEC GPC/SEC system, which combines all the detectors described above.
Automation > Laboratory Instrumentation > White Papers
Structure-Molecular Weight Relationships of Synthetic Polymers
| By Malvern Instruments
In this application note, the structural distributions of some common polymers are compared using the Mark-Houwink plot. The data are all generated using the Malvern OMNISEC system shown in Figure 1.
Automation > Laboratory Instrumentation > White Papers
Measurements of Absolute Molecular Weight of Synthetic Polymers using OMNISEC
| By Malvern Instruments
In this application note, the molecular weight, molecular weight distribution and size of common polymers are measured using the OMNISEC system.
Automation > Laboratory Instrumentation > White Papers
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 3. DLS Deconvolution Algorithms
| By Malvern Instruments
In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. In this third white paper of the series, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.
Automation > Laboratory Instrumentation > White Papers
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 2. Concentration Effects and Particle Interactions
| By Malvern Instruments
In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. In this second white paper of the series, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.
Automation > Laboratory Instrumentation > White Papers
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations:Principles, Measurements and Analysis - 1. Basic Principles
| By Malvern Instruments
This four-part white paper series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimise the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. Here, in Part One of this series, we provide an overview of the key principles of DLS: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform.
Automation > Laboratory Instrumentation > White Papers
1-15 of 140 results