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Laboratory Instrumentation White Papers

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1-15 of 187 results
The Benefits of Real-Time Analysis for Process Development
| By Malvern Instruments
While much effort is expended in optimizing commercially operating plant, getting the process 'right first time' can be far more efficient. Real-time analysis of process parameters provides substantial support during development, streamlining and accelerating the evolution of successful process designs. Taking on-line particle size analysis as an example, this paper considers the rationale for investing in real-time measurement for pilot scale work. Case studies illustrate the various ways in which on-line systems promote efficient process development, easing the transition into profitable manufacture.
Automation > Laboratory Instrumentation > White Papers
Understanding Yield Stress Measurements
| By Malvern Instruments
Many complex fluids, such as network forming polymers, surfactant mesophases, emulsions etc do not flow until the applied stress exceeds a certain critical value, known as the yield stress. Materials exhibiting this behavior are said to be exhibiting yield flow behavior. The yield stress is therefore defined as the stress that must be applied to the sample before it starts to flow. Below the yield stress the sample will deform elastically (like stretching a spring), above the yield stress the sample will flow like a liquid.
Automation > Laboratory Instrumentation > White Papers
Towards a Unified Biophysical Characterization Platform: Combining Dynamic Light Scattering and Raman Spectroscopy to Determine Protein Structure and Stability
| By Malvern Instruments
The combination of dynamic light scattering (DLS) with Raman spectroscopy has the capability to characterize a wealth of chemical, structural, and physical parameters of therapeutic proteins. Raman spectroscopy simultaneously derives protein secondary structure markers (amide I and III) and tertiary structure markers (aromatic side chains, disulfide bond, hydrogen bonding, local hydrophobicity). These markers can be monitored under controlled conditions by the determination of spectral peak position, shape, and/or intensity. Raman is able to make these structural determinations at formulation concentrations, 50 mg/mL or greater, rather than at the diluted concentrations required by conventional methods, i.e. typically less than a few mg/mL for circular dichroism (CD).
Automation > Laboratory Instrumentation > White Papers
XRD SYSTEMS
| By PANalytical
Supporting the pharmaceutical industry with 21 CFR Part 11 compliance readiness.
Automation > Laboratory Instrumentation > White Papers
Top Ten Things to Consider When Migrating to the Mastersizer 3000 from the Mastersizer 2000
| By Malvern Instruments
Previously, we've published 11 things to consider when purchasing a laser diffraction system. With the launch of the Mastersizer 3000, how can you choose between the Mastersizer 3000 and the popular Mastersizer 2000 that has sold more than 11,000 units worldwide? This white paper outlines the new capabilities of the Mastersizer 3000 and highlights the support Malvern provides to help you transfer methods from the Mastersizer 2000 to the new system.
Automation > Laboratory Instrumentation > White Papers
Nanoscale Material Characterization: a Review of the use of Nanoparticle Tracking Analysis (NTA)
| By Malvern Instruments
This white paper describes the central role of high resolution particle size and concentration measurement nanoparticle research. The technique of Nanoparticle Tracking Analysis (NTA) is described and compared to other characterization methodologies, and comparative papers are cited. A wide range of application studies is then summarized with specific reference to the use and value of NTA.
Automation > Laboratory Instrumentation > White Papers
Characterization of Single Wall Carbon Nanotubes (SWNTs) by combining Dynamic Light Scattering and Raman Spectroscopy
| By Malvern Instruments
The combination of DLS and Raman spectroscopy offers the ability to measure the length, diameter, and chirality of carbon nanotubes in a single experiment. These parameters can be used with existing empirical knowledge of nanotubes to predict their conductivity and strength characteristics.
Automation > Laboratory Instrumentation > White Papers
Measuring the Rheology of Polymer Solutions
| By Malvern Instruments
Polymers are versatile materials that play an important role in a diverse range of industrial applications. Polymeric solutions or suspensions provide joint lubrication in the human body, make foods appear rich and creamy, and impart stability to inks and paints. In these and many other applications the rheological characteristics of the polymer solution have a defining influence on product performance and functionality.
Automation > Laboratory Instrumentation > White Papers
Supporting the Pharmaceutical Industry with 21 CFR Part 11 Compliance Readiness
| By PANalytical
The purpose of this document is to describe how PANalytical systems support system owners meeting the requirements of the 21 CFR Part 11 regulations issued by the United States' FDA (Food & Drug Administration).
Automation > Laboratory Instrumentation > White Papers
The Use of EDXRF for Pharmaceutical Material Elemental Analysis
| By PANalytical
This study demostrates that the X-ray Fluorescence (XRF) technique is capable of performing elemental analysis of all of these pharmaceutical (liquid, powder and solid) materials with high sensitivity, precision and accuracy.
Automation > Laboratory Instrumentation > White Papers
Exosomes and Microvesicles: Characterization by Nanoparticle Tracking Analysis
| By Malvern Instruments
NTA utilizes the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualized via a 20x magnification microscope onto which is mounted a camera.
Automation > Laboratory Instrumentation > White Papers
Differential Scanning Calorimetry: Theory and Practice
| By Malvern Instruments
The key benefit with DSC is that it is based on heat measurements and therefore allows the characterization of native biomolecules. Furthermore, the lack of spectroscopic readings means that the samples do not have to be optically clear. In addition, the characterization is not limited to the melting temperature (Tm), but it also provides data on the forces involved in folding of biomolecules and the mechanisms by which they unfold.
Automation > Laboratory Instrumentation > White Papers
Ten Ways to…..Control Rheology by Changing Particle Properties (Size, Zeta Potential and Shape)
| By Malvern Instruments
Many common materials can be considered to be dispersions in which one substance (often particulate) is dispersed in another phase. These material types include adhesives, agrochemicals, cement, ceramics, colloids, cosmetics and personal care formulations, food and drink, mining and mineral slurries, paints, inks and surface coatings, pharmaceuticals and polymer systems.
Automation > Laboratory Instrumentation > White Papers
Truly Parallel - Microbiology
| By Eppendorf
DASGIP® Bioreactor Systems for Microbiology.
Automation > Laboratory Instrumentation > White Papers
Truly Parallel - Cell Culture
| By Eppendorf
DASGIP® Bioreactor Systems for Cell Culture Applications.
Automation > Laboratory Instrumentation > White Papers
1-15 of 187 results