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Laboratory Instrumentation White Papers

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1-15 of 135 results
New Parsum Probe IPP 80-P
| By Malvern Instruments
Parsum presented a new probe type on the Powtech (30. Sep – 02 Oct 2014) in Nuremberg. The IPP 80-P is especially made for application in pharma industry. Design is completely in stainless steel and it will be available only as an ATEX certified type. The USB-box will be integrated into the barrier housing, so cabling and installation will become simpler.
Automation > Laboratory Instrumentation > White Papers
An Introduction to OMNISEC REVEAL
| By Malvern Instruments
This technical note describes the system and explains how OMNISEC sets a new standard in molecular characterization.
Automation > Laboratory Instrumentation > White Papers
An Introduction to OMNISEC RESOLVE
| By Malvern Instruments
This technical note describes the features and benefits of OMNISEC RESOLVE. It also includes a discussion of the value of OMNISEC as a complete system as opposed to upgrading an existing conventional system to advanced detection.
Automation > Laboratory Instrumentation > White Papers
The Mark–Houwink plot – Differentiation of Branching and Composition
| By Malvern Instruments
In this application note, we will show how to separate the effects of a structural difference induced by a compositional change to a polymer (e.g. substitution) and the structural change induced by polymer chain branching.
Automation > Laboratory Instrumentation > White Papers
GPC/SEC Analysis of Polylactic Acid (PLA) and Poly(lactic-co-glycolic acid) (PLGA) Using OMNISEC
| By Malvern Instruments
In this application note, a selection of different PLA and PLGA polymer samples were analyzed on Malvern's OMNISEC GPC/SEC system, which combines all the detectors described above.
Automation > Laboratory Instrumentation > White Papers
Structure-Molecular Weight Relationships of Synthetic Polymers
| By Malvern Instruments
In this application note, the structural distributions of some common polymers are compared using the Mark-Houwink plot. The data are all generated using the Malvern OMNISEC system shown in Figure 1.
Automation > Laboratory Instrumentation > White Papers
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 3. DLS Deconvolution Algorithms
| By Malvern Instruments
In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. In this third white paper of the series, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.
Automation > Laboratory Instrumentation > White Papers
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 2. Concentration Effects and Particle Interactions
| By Malvern Instruments
In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. In this second white paper of the series, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.
Automation > Laboratory Instrumentation > White Papers
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations:Principles, Measurements and Analysis - 1. Basic Principles
| By Malvern Instruments
This four-part white paper series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimise the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. Here, in Part One of this series, we provide an overview of the key principles of DLS: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform.
Automation > Laboratory Instrumentation > White Papers
Ten Reasons That the Zetasizer Nano is Chosen for Scientific Success
| By Malvern Instruments
New components and measurement techniques continue to be introduced for the Zetasizer Nano. New to the system are a Surface Zeta Potential accessory and a new diffusion barrier method for improved zeta potential measurements of protein samples. Why is the Malvern Zetasizer Nano so popular and found in a broad range of applied and fundamental scientific projects across all industries and fields? Because, it is simply the most dynamic and broad ranged instrument on the market for solving technical issues in today's research environment and it continues to evolve with new capabilities. Here are ten reasons why you should choose the Zetasizer Nano:
Automation > Laboratory Instrumentation > White Papers
Exosomes and Microvesicles: Characterisation by Nanoparticle Tracking Analysis
| By Malvern Instruments
While the principles underpinning the Nanoparticle Tracking Analysis (NTA) technique have been described in an earlier white paper, it must be reiterated that the use of high intensity laser beams combined with a low-background optical configuration allows particles of deeply sub-micron dimensions to be visualised, the lower range of particle sizes measureable depending on particle refractive index.
Automation > Laboratory Instrumentation > White Papers
Viruses and Viral Vaccines: Characterisation by Nanoparticle Tracking Analysis
| By Malvern Instruments
NTA utilises the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualised via a 20x magnification microscope onto which is mounted a camera. The camera, which operates at approximately 30 frames per second (fps), captures a video file of the particles moving under Brownian motion within the field of view of approximately 100μm x 80 μm x 10 μm (Figure 1).
Automation > Laboratory Instrumentation > White Papers
How can Nanoparticle Tracking Analysis Assist in the Production of Nanoparticles
| By Malvern Instruments
This white paper highlights the growth in the use of the technique of Nanoparticle Tracking Analysis as applied to nanoparticles and nanomaterials production and analysis, from the very first reports on nanoscale silver and gold (Lundahl et al. (2008) and Marsh et al. (2008), respectively).
Automation > Laboratory Instrumentation > White Papers
Studying Low-Affinity Fragments of Ligands by ITC
| By Malvern Instruments
Molecular recognition is a fundamental prerequisite to all biological processes from enzymatic catalysis to signal transduction. The modern pharmaceutical industry is built upon the concept of selective intervention in such systems (1). Furthermore, similar concepts are being implemented, through supramolecular chemistry, to develop novel smart materials, components for nanotechnology and molecular electronics (2). If we are to harness the full potential of molecular recognition, it is essential that we understand the subtle interplay between structure and thermodynamics in complex formation.
Automation > Laboratory Instrumentation > White Papers
1-15 of 135 results