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Laboratory Instrumentation White Papers

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1-15 of 195 results
Estimating BSA Aggregation Kinetics with Dynamic Light Scattering and Raman Spectroscopy
| By Malvern Instruments
Towards a unified biophysical characterization platform: Combining dynamic light scattering and Raman spectroscopy*.
Automation > Laboratory Instrumentation > White Papers
An Introduction to DLS Microrheology
| By Malvern Instruments
Microrheology techniques involve tracking the motion of dispersed probe (or tracer) particles in a complex fluid, to extract local and bulk rheological properties of the matrix. Analogous to mechanical rheometry techniques, a stress is applied to the system by motion of the probe particle, and the deformation (or strain) is measured through changes in the probe particle position.
Automation > Laboratory Instrumentation > White Papers
A Basic Guide to Particle Characterization
| By Malvern Instruments
The aim of this guide is to provide a basic grounding in the main particle characterization techniques currently in use within industry and academia. It assumes no prior knowledge of particle characterization theory or instrumentation and is ideal for those new to particle characterization, or those wishing to reinforce their knowledge in the field. The guide covers introductory basics, particle sizing theory and particle characterization instrumentation, as well as a quick reference guide to help you decide which techniques might be most appropriate for your particle characterization needs. It is not inclusive of all particle characterization techniques; more information can be found at www.malvern.com.
Automation > Laboratory Instrumentation > White Papers
Autoinjectors From Planning to Launch
| By SHL Group
Injectable drug delivery devices such as pen injectors and autoinjectors show a significant growth potential in the future. This white paper focuses on the development process of an autoinjector project from planning to launch and best practices on how to prepare for and address potential challenges along the way.
Automation > Laboratory Instrumentation > White Papers
NTA: Nanoparticle Toxicity
| By Malvern Instruments
At the same time as an increasing interest in, and rapid development of, a wide range of materials and products containing nanoscale structures and engineered nanoparticles, awareness has grown that the longer term potential toxic effects of such materials and their potential environmental impact are poorly understood. Existing methods have been assessed and new methods sought by which such materials could be analyzed on a routine basis during development and manufacture.
Automation > Laboratory Instrumentation > White Papers
Orthogonal and Complementary Nanoparticle Characterization Techniques
| By Malvern Instruments
How can I trust my data? This is a common concern for many researchers using particle measurement instrumentation. Is the data affected in any way by the measurement technology, or alternatively by the user during sample preparation or by the analysis parameters employed? To answer this question we need to consider the use of independent and orthogonal measurement techniques in order to provide confidence and measurement validation.
Automation > Laboratory Instrumentation > White Papers
The Benefits of Real-Time Analysis for Process Development
| By Malvern Instruments
While much effort is expended in optimizing commercially operating plant, getting the process 'right first time' can be far more efficient. Real-time analysis of process parameters provides substantial support during development, streamlining and accelerating the evolution of successful process designs. Taking on-line particle size analysis as an example, this paper considers the rationale for investing in real-time measurement for pilot scale work. Case studies illustrate the various ways in which on-line systems promote efficient process development, easing the transition into profitable manufacture.
Automation > Laboratory Instrumentation > White Papers
Understanding Yield Stress Measurements
| By Malvern Instruments
Many complex fluids, such as network forming polymers, surfactant mesophases, emulsions etc do not flow until the applied stress exceeds a certain critical value, known as the yield stress. Materials exhibiting this behavior are said to be exhibiting yield flow behavior. The yield stress is therefore defined as the stress that must be applied to the sample before it starts to flow. Below the yield stress the sample will deform elastically (like stretching a spring), above the yield stress the sample will flow like a liquid.
Automation > Laboratory Instrumentation > White Papers
Towards a Unified Biophysical Characterization Platform: Combining Dynamic Light Scattering and Raman Spectroscopy to Determine Protein Structure and Stability
| By Malvern Instruments
The combination of dynamic light scattering (DLS) with Raman spectroscopy has the capability to characterize a wealth of chemical, structural, and physical parameters of therapeutic proteins. Raman spectroscopy simultaneously derives protein secondary structure markers (amide I and III) and tertiary structure markers (aromatic side chains, disulfide bond, hydrogen bonding, local hydrophobicity). These markers can be monitored under controlled conditions by the determination of spectral peak position, shape, and/or intensity. Raman is able to make these structural determinations at formulation concentrations, 50 mg/mL or greater, rather than at the diluted concentrations required by conventional methods, i.e. typically less than a few mg/mL for circular dichroism (CD).
Automation > Laboratory Instrumentation > White Papers
XRD SYSTEMS
| By PANalytical
Supporting the pharmaceutical industry with 21 CFR Part 11 compliance readiness.
Automation > Laboratory Instrumentation > White Papers
Top Ten Things to Consider When Migrating to the Mastersizer 3000 from the Mastersizer 2000
| By Malvern Instruments
Previously, we've published 11 things to consider when purchasing a laser diffraction system. With the launch of the Mastersizer 3000, how can you choose between the Mastersizer 3000 and the popular Mastersizer 2000 that has sold more than 11,000 units worldwide? This white paper outlines the new capabilities of the Mastersizer 3000 and highlights the support Malvern provides to help you transfer methods from the Mastersizer 2000 to the new system.
Automation > Laboratory Instrumentation > White Papers
Nanoscale Material Characterization: a Review of the use of Nanoparticle Tracking Analysis (NTA)
| By Malvern Instruments
This white paper describes the central role of high resolution particle size and concentration measurement nanoparticle research. The technique of Nanoparticle Tracking Analysis (NTA) is described and compared to other characterization methodologies, and comparative papers are cited. A wide range of application studies is then summarized with specific reference to the use and value of NTA.
Automation > Laboratory Instrumentation > White Papers
1-15 of 195 results