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Laboratory Instrumentation White Papers

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1-15 of 95 results
Point of Care Testing in Clinical Trials
| By Woodley Equipment Company
Point of care (POC) testing is diagnostic testing performed in the vicinity of the patient, avoiding the need to send samples to a central laboratory. Results generated by POC devices can be utilised in clinical trials as decision-makers prior to administering treatments or results can be used as actual trial data.
Automation > Laboratory Instrumentation > White Papers
User vs. Software-Dependent Variability of ELISPOT Counts Obtained from ten Different Laboratories
| By CTL Laboratories
In ELISPOT assays, cytokine spots produced by antigen-specific T cells show a broad spectrum of sizes and densities over variable background. Therefore, even experienced investigators are likely to come up with different spot counts when subjectively judging the minimal spot size/density to be counted and the maximal spot size for the cut off between singlecell-derived spots vs. those created by cell clusters. This study aims to find out whether statistics-based automated gating can harmonize spot counts obtained in different laboratories.
Automation > Laboratory Instrumentation > White Papers
ELISPOT Assays Provide Reproducible Results Among Different Laboratories for T-cell Immune Monitoring - Even in Hands of ELISPOT's Inexperienced Investigators
| By CTL Laboratories
Measurements of antibodies in bodily fluids (e.g., by ELISA) have provided robust and reproducible results for decades and such assays have been validated for monitoring of B-cell immunity. In contrast, measuring T-cell immunity has proven to be a challenge due to the need to test live cells in functional assays ex vivo. Several previous efforts looking into the reproducibility of ex vivo T-cell assays between different laboratories, or even within the same laboratory, have provided rather discouraging results.
Automation > Laboratory Instrumentation > White Papers
How Frequently are Predicted Peptides Actually Recognised by CD8 Cells?
| By CTL Laboratories
Detection of antigen-specific CD8 cells relies on the use of peptides that can bind to HLA-Class I molecules. There is extensive knowledge on individual HLA-alleles’ peptide binding requirements and for many antigens immunogenic peptides have been defined. The 32 individual peptides that comprise the CEF peptide pool represent such well-defined peptide determinants for Cytomegalo, Epstein Barr, and Flu virus. We tested 42 healthy human donors on the accuracy of these peptide predictions.
Automation > Laboratory Instrumentation > White Papers
Publications by Theme
| By CTL Laboratories
For over 15 years, Prof. Lehmann and the team of scientists working with him have been focused on establishing the scientific foundations of ELISPOT assays and to test the utility of the technology in various fields of T cell diagnostics. CTL’s peer-reviewed publications are listed here by theme with the hopes of providing a useful reference for your research.
Automation > Laboratory Instrumentation > White Papers
Characterisation of the CMV-Specific CD4 Cell Response
| By CTL Laboratories
Most humans become infected with HCMV. Typically, the immune system controls the infection, but the virus persists and can reactivate in states of immunodeficiency. While the HCMV-specific CD8 cell and antibody response has been accessible to investigation, studies of the CD4 cell subsets have been limited by the low frequency of the antigen-specific CD4 cells in PBMC.
Automation > Laboratory Instrumentation > White Papers
How the Vaisala Continuous Monitoring System Aids Compliance with Title 21 CFR Part 11 and EU GMP Annex 11
| By Vaisala pbr
This white paper outlines how Vaisala’s Continuous Monitoring System helps to meet the requirements of Title 21 CFR Part 11 and EU GMP Annex 11 as they apply to environmental monitoring and validation.
Automation > Laboratory Instrumentation > White Papers
GMP Warehouse Mapping - Step-by-Step Guidelines for Validating Life Science Storage Facilities
| By Vaisala pbr
This step-by-step paper describes how to map a warehouse to comply with internationally recognized GMPs and regulatory requirements.
Automation > Laboratory Instrumentation > White Papers
Monitoring Systems - Sorting Out Wireless
| By Vaisala pbr
This white paper describes the most common methods of connecting sensors to a monitoring system focusing on selecting wireless options.
Automation > Laboratory Instrumentation > White Papers
Nine Things you Need to Know About Continuous Monitoring Systems in FDA-Regulated Environments
| By Vaisala pbr
The white paper outlines nine crucial evaluation points that will allow you to select the monitoring system best suited to your monitored applications, controlled environments and GxP facilities.
Automation > Laboratory Instrumentation > White Papers
A Unique Solution for Generation of Reliable Intracellular Cytokine Staining Data
| By BD Biosciences
The BD FACSVerse™ system is a high-performance flow cytometer that incorporates easy-to-use, task-based workflows that streamline every stage of operation. A predefined assay module based on the BD FastImmune™ intracellular cytokine detection kits offers a quick and easy solution to generate reliable and consistent intracellular cytokine staining data. It can also be used as a starting point for creating custom assays. For more information please download this free Application Note.
Automation > Laboratory Instrumentation > White Papers
Bioprocess Monitoring Using a Compact Flow Cytometer
| By BD Biosciences
The BD Accuri™ C6 flow cytometer offers a powerful and effective methodology for monitoring microbial fermentation, allowing measurement of cell viability, vitality, and other important cell characteristics. It also interfaces smoothly with automated bioreactor sampling systems, giving bioprocess engineers access to real-time, online bioreactor data for pinpoint process control. For more information please download this free Application Note.
Automation > Laboratory Instrumentation > White Papers
Streamlined Cell Cycle Analysis Using a BrdU-Based Flow Cytometry Assay
| By BD Biosciences
The BD FACSVerse™ system is a high-performance flow cytometer that incorporates easy-to-use, task-based workflows that streamline every stage of operation. A predefined assay module for BrdU-incorporation assays offers a quick and easy solution to cell cycle analysis using flow cytometry, which is able to resolve cell cycle phases in a given cell population into G0/G1, S and G2+M phases. It can also be used as a starting point for creating custom assays. For more information please download this free Application Note.
Automation > Laboratory Instrumentation > White Papers
Standardisation and Portability of Flow Cytometry Assays for Collaborative Studies
| By BD Biosciences
To conduct collaborative and longitudinal flow cytometry based studies, standardisation of flow cytometry instruments is essential for obtaining consistent and reproducible results. The BD FACSVerse™ system addresses these needs. Cytometer settings are reusable on the same system on different days for longitudinal studies and are transportable across different BD FACSVerse systems for multisite studies. For more information please download this free Application Note.
Automation > Laboratory Instrumentation > White Papers
1-15 of 95 results