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Shimadzu - Analytical Instrumentation White Papers

Shimadzu - Analytical Instrumentation

Pharma News Special For the latest pharmaceutical industry news from Shimadzu, please download the free White Paper below.
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Dual Ion Source DUIS-2020 for Simultaneous ESI and APCI Measurement In LCMS measurement, the ionization mode is selected depending on the polarity of the target compounds. For example, Electrospray Ionization (ESI) is generally selected for analysis of high-polarity compounds which are typically found in drugs and pesticides, while Atmospheric Pressure Chemical Ionization (APCI) is selected for compounds having lower polarity.
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Reduced Solvent Consumption and Operational Costs with Existing LC Systems Switching to the Prominence UFLC ultra-high-speed LC as a means of reducing solvent consumption and operational costs was introduced in Technical Report No. 24 "Reduced Solvent Consumption and Operational Costs with Ultra High Speed Analysis." Although introduction of ultra-highspeed LC is an effective way to conserve solvent, there is a very significant issue as to how this can be achieved with the existing LC systems in use. This report introduces detailed suggestions on how to most effectively reduce solvent consumption with existing LC systems.
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Reduced Solvent Consumption and Operational Costs with Ultra High Speed Analysis HPLC-grade acetonitrile and methanol are used in many applications due to their chemical stability and low impurity content. Acetonitrile is generally used as a mobile phase more than methanol because (1) it subjects the column to less pressure to permit a longer column life, and (2) there are fewer obstructions in the short wavelength region in UV detection.
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Reducing Analysis Limitations by Using Multiple Detectors with Ultra-Fast LC In HPLC method development, it is important not only to focus on the substance of interest, but also to pay attention to impurities. In both process and quality control, care must be taken with respect to unanticipated impurities in the sample to maintain a high level of product quality. When using ultra fast LC in particular, appropriate measures must be taken to ensure that impurities are not overlooked during the shortened analysis time achieved with higher speeds.
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Improved R&D Efficiency in Compound Synthesis, Confirmation and Purification Research departments in various fields, especially those in the pharmaceutical manufacturing and chemical-industries, are involved in the synthesis of compounds and the subsequent confirmation and purification of those compounds. Often, the greatest major concern of researchers handling great numbers of samples is how to achieve data as quickly and easily as possible.
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Accurate Mass Measurement of High Concentration Samples by LCMS-IT-TOF Time of flight (TOF) type mass spectrometers are used because they are capable of providing accurate high-resolution mass information. Mass accuracy for TOF analysers can deteriorate under certain conditions when analysing high concentration samples
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Curse of the Pharaohs? Analysis of Mycotoxins Unfortunately, mycotoxin-contaminated foods cannot be recognized as such and accidental mycotoxin exposure cannot be ruled out. Therefore, it is important to establish straightforward and fast analytical methods for the detection of mycotoxins.
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Improved R&D Efficiency Through Speedier Method Development (1) Various approaches are available for improving the efficiency of analytical method development. The introduction of high-speed analysis into the method development process for LC and LC/MS is one approach that can directly enhance development efficiency by simply speeding up chromatographic evaluation.
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Improved R&D Efficiency Through Speedier Method Development (2) Typically, when developing an HPLC analytical method, it is necessary to optimise multiple parameters, including the analytical column phase and eluent type, and the column temperature, flow rate, etc.
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LCMS-2020 - Reduces Limitations of HPLC Analysis and UFLC Analysis One of the biggest issues for HPLC is faster analysis, and this requirement is being addressed with the ultra fast LC “Prominence UFLC”. The ultimate in speed, superb repeatability and enhanced performance provided by this instrument have permitted penetration of UFLC analysis into many different fields.
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