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Using Differential Scanning Calorimetry to Inform and Accelerate Process Development for Protein Therapeutics

Published 31 May 2016 | By Malvern Panalytical

The production and purification of immunoglobulins of the gamma isotype, particularly human IgG1, for diagnostic or therapeutic applications is now fairly routine. In the past decade IgE-based therapeutics have also gained momentum (1-3). IgE is important for host defense against parasites and for protective inflammation. Yet, IgE-mediated signaling through its receptors is also a focal point of inflammatory allergic disease (4). The constant region of IgE, is a homodimer containing duplicate pairs of three unique Ig-fold domains (Cε2, Cε3, and Cε4), and is responsible for binding its two receptors, FcεRI and CD23, also known as FcεRII.

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Using Differential Scanning Calorimetry to Inform and Accelerate Process Development for Protein Therapeutics