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Applications of Isothermal Titration Calorimetry and Differential Scanning Calorimetry in Biopharmaceutical

Published 29 September 2014 | By Malvern Instruments

Development of protein-based therapeutics is a challenging task due to inherent protein instabilities, which can manifest as physical instability (unfolding, aggregation, adsorption), and chemical degradation (oxidation, deamidation, cleavage). Such instabilities can lead to reduced activity of the protein or even generation of potentially immunogenic species.

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Applications of Isothermal Titration Calorimetry and Differential Scanning Calorimetry in Biopharmaceutical