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Malvern Instruments – Pharmaceutical Equipment Supplier Case Studies

Malvern Instruments – Pharmaceutical Equipment Supplier

Malvern Instruments explores how Switching Mobile Phases can Improve your OMNISEC Results Analysis of ester- and acid-capped PLGA samples in mobile phases of DCM and THF.
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Malvern Instruments: Multi-detector GPC/SEC analysis of polysaccharides using OMNISEC How moving to multi-detector GPC can give greater insight than conventional measurements.
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Processing non-Newtonian products: Determining the pressure drop for a power law fluid along a straight circular pipe In the chemical and process industries, it is often required to pump fluids over long distances from storage to various processing units and/or from one plant site to another. It is thus often necessary to calculate the pressure requirements for pumping, the selection of optimum pipe diameter as well as measurement and control of flow rate. Many of the formulae required to estimate such parameters are available in the literature and require some knowledge of these processing parameters as well as fluid properties.
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MicroCal PEAQ-DSC Brochure by Malvern Instruments Biomolecular stability analysis for the regulated environment
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How investing in Malvern Instruments helped KBI Biopharma find a clear commercial advantage Written by Dr. Amber Fradkin of KBI Biopharma, who manages the Particle Characterization Core Facility at KBI Biopharma in Boulder, Colorado.
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Using Squeeze Flow to Extend Rheological Measurements for Concentrated Suspensions Making shear rheological measurements on samples with a high solids fraction can present difficulties on a rotational rheometer, since the sample can be prone to fracture even at low-medium shear rates.
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Using Laser Diffraction to Characterize Casein Micelles and Fat Globules in Milk To improve its shelf-life, milk undergoes a homogenization process. This process produces fat globules of a uniform, small size. During the homogenization process the size range of the fat globules is reduced from 0.1-15 μm in unprocessed milk to 1-2 μm in homogenized milk [1]. These smaller globules cannot form large enough clusters for creaming to occur, increasing the shelf-life of the milk.
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Introducing Morphologically-Directed Raman Spectroscopy A powerful tool for the detection of counterfeit drugs
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Time to Harness the True Power of Rheology Upgrading from a viscometer to a modern rotational rheometer brings access to a range of test methods that can be applied to accelerate and enhance the formulation of personal care products
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On the Same Wavelength: Calcium Carbonate Particle Size and Laser Technology Malvern Instruments embarks on particle size analysis of carbon carbonates by utilising laser diffraction, a technique adopted for the use of sizing particles in materials of vastly different parameters.
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Nothing's Set in Stone: Component Characterization of Cements using Morphologi G3-ID Via technology that features static, automated imaging combined with Raman spectroscopy, Malvern Instruments examines the characteristics and behaviours of individual cement components.
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A Thirst for Knowledge: Malvern Instruments Monitors Microfiltration Processes for Water Treatment Malvern dives into quantifying nanoparticle concentration and size to optimize filtration processes
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The Dynamism of DSC in Membrane Behaviour To reveal the basics of liposome sample preparation and DSC studies, Malvern Instruments uses this fundamental technique to characterize thermotropic phase transitions in lipid bilayer membranes
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Characterization of Protein-Protein Interactions using Triple Detection Size Exclusion Chromatography (SEC-TD) The ability of proteins to form ordered, structured complexes is central to their biological function. Such complexes, which can be homo-oligomers or heterooligomers, can control different attributes such as activity, stability and localization. Understanding how these complexes form, and the controlling mechanism behind them, is fundamental to our knowledge of protein signaling pathways and the physiological responses they control.
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Comparing the Rheology and Particle Size of Smoothies Made with Different Blenders Smoothies have been around for the best part of a century although it was not until the development, commercialization and evolution of the blender between 1920 and 1950 that home-made smoothies (in the modern sense) became possible. Their popularity was further accelerated by the health food movement of the 1960’s and more recently the commercialization of dedicated smoothie makers, combined with a trend towards natural and nutritious foods.
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Evaluating Product Spreading Characteristics on a Rotational Rheometer Using the Power Law Model The rheological properties of a product can influence how it is visually and texturally perceived by a consumer and how it is likely to behave during product use. For example very shear thinning materials will be highly responsive to changes in applied stress while Newtonian materials will show much lesser dependence. Such a response is important when considering the ease of spreading or ‘spread-ability’.
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Analysis of Demicellization Data from Isothermal Titration Calorimetry Many industrial and biochemical applications depend on the usage of detergents and other surfactants. These compounds are indispensable, in particular, for the extraction, purification, and handling of membrane proteins. Owing to their amphiphilic nature, detergents can provide a membrane-mimetic environment required by integral membrane proteins to retain their native structures and functions in aqueous solution. Oftentimes, different detergents have to be screened to identify one that is suitable for the solubilization, stabilization, reconstitution, and biophysical, biochemical, or structural scrutiny of the protein of interest.
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Optimizing Fluid Rheology for Enhanced Oil Recovery Applications In this case study we present elements of the work carried out by Rafael Hincapie as part of his PhD project at TU Clausthal to better understand how viscoelastic properties of EOR polymers influence oil recovery performance. We show how non-linear viscoelastic measurements made on a rotational rheometer can be used to help explain the behavior of viscoelastic polymers in the porous media and how this behaviour is influenced by environmental conditions.
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Characterization of IgG Monomers & Their Aggregates A comparison between column calibration & multi-detection SEC.
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Optimization of PLA/PLGA Molecular Weight and Structure to Suit Final Application Requirements The biodegradable and biocompatible polymers, PLA and PLGA are used in many different applications including, amongst others, food packaging, farming materials, biomedical devices such as absorbable surgical thread and implants such as stents or drug release systems. 3D-printing is another application which benefits from the low melt processing temperature of PLA. Usually, PLA and PLGA are based on monomers from renewable sources, so are considered "green" polymers. By selecting different molecular weights, different ratios of lactic:glycolic acid and different molecular structures, some properties such as degradation or drug release rates can be tailored to meet application needs. GPC/SEC analysis is an ideal tool for monitoring samples during material synthesis, production of parts and in degradation studies.
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Differentiation of Polymer Branching and Composition Using the Mark–Houwink Plot In this application note, we will show, using polystyrene, how to separate the effects of a structural difference induced by a compositional change (bromination) and the structural change induced by polymer chain branching using the Mark- Houwink plot.
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Polyol-Induced Increases in Thermal Stability of Antibodies by DSC To date, no systematic study has been performed using multiple proteins to address whether different stereoisomers of a polyol would induce more or less thermal stability on a protein. The goal of the study was to understand how the size of a polyol and orientation of the hydroxyl group influence the amount of thermal stability that could be induced upon seven monoclonal antibodies of different isotypes. In order to monitor thermal stability, differential scanning calorimetry (DSC) has been employed. DSC has been used to monitor the unfolding of proteins due to heat denaturation in order to study the unfolding of the domains of an antibody,monitor thermal reversibility, and screen formulations for excipients.
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The Application of MicroCal VP Capillary DSC at a Contract Development Organization Although biopharmaceuticals represent a rapidly growing segment for ethical products, the ability to progress these products from research to development and ultimately manufactured products can be hindered by the complex structures and multiple degradation pathways that are associated with biopolymers.
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Engineering Monoclonal Antibodies to Enhance Drugability In this manuscript we compare the stability of three different engineered antibodies as determined by SEC-HPLC analysis during accelerated stability studies, with the stability predicted by DSC. The results demonstrate a correlation between decreased thermostabilty based on DSC data, and greater aggregation formation during accelerated stability studies for the antibodies studied. Thus, the results demonstrate how DSC can be a useful tool in stability screening of engineered proteins.
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How Malvern MicroCal ITC Adds Value in Drug Discovery with Applications from Assay Development to Lead Optimization The goal of pharmaceutical research is to modulate the activity of a target such that a therapeutically beneficial response is evoked. A drug is normally only efficacious when bound to and modulating the activity of its physiological target(s). Consequently much early-phase drug discovery is focused on the optimization of a drug candidate’s target affinity and selectivity.
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Characterizing the Microstructure of ‘worm-like micelles’ Using Rheology The properties of worm-like micelles (WLMs) represent a key research area in both academia and industry. This is primarily due to the fact that they have widespread applications across a range of industries ranging from Personal Care to Oil Recovery. They offer a simple, cost effective way to generate remarkable viscosity and viscoelasticity.
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Measuring the Particle Size of Small Sample Volumes Using Laser Diffraction It can often be the case that the volume of sample available for particle size analysis is minimal. For example, in the pharmaceutical and catalysis industries it may be necessary to determine the particle size distribution early in the product development cycle, when only a few milligrams of material have been synthesized. This requires the ability to perform reliable measurements on a small volume of sample, and it is desirable to be able to recover the sample for further testing.
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Use of Microcalorimetry and its Correlation with Size Exclusion Chromatography for Rapid Screening of the Physical Stability of Large Pharmaceutical Proteins in Solution During the past two decades, there has been a rapidly increasing interest in development and commercialization of protein-based therapeutics. One of the greatest challenges during development for such products is the stabilization of proteins in solution. To address this issue, many proteins are formulated as a lyophile that must be reconstituted with a suitable vehicle just prior to use.
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Microcalorimetry as a Tool for Structural Biology Crystallization of complexes (protein/protein, protein/nucleic acid, protein/ ligand, nucleic acids/nucleic acid, nucleic acid/ligand), even on well-characterized biological systems, are frequently tedious and either time or sample consuming. The success rate of complex crystallization can be significantly improved if a proper preliminary characterization of the complex using biophysical methods is performed. It well established that Dynamic Light Scattering (DLS) is key to evaluate sample crystallizability (1).
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Discriminating Between Polymorphs of Acetaminophen Using Morphologically-Directed Raman Spectroscopy (MDRS) Interest in studying mixed systems of pharmaceutical relevance is not a new concept. From intrinsic polymorphism to complex final products, the challenges encountered by modern analytical scientists have multiplied both in number and in complexity.
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