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Laboratory Instrumentation

Cepheid, pharma firms collaborate on diagnostic test for multidrug-resistant bacterial infections By PBR Staff Writer
Cepheid has entered into a new collaboration with AstraZeneca, Cubist and GSK to encourage transformational change in infectious disease therapy.
Automation > Laboratory Instrumentation > News
BioLight announces start of clinical study with DiagnosTear dry eye syndrome diagnostic assay BioLight Life Sciences Investments announced that DiagnosTear has received all necessary approvals from Sheba Medical Center near Tel Aviv to begin a clinical study with its TeaRx, point-of-care Dry Eye Syndrome diagnostic assay. DiagnosTear is part of BioLight’s XLVision Sciences ophthalmology cluster.
Automation > Laboratory Instrumentation > News Hepregen launches first application-oriented in vitro kit By PBR Staff Writer
Bioengineered micro-liver platforms developer Hepregen has launched its first application-oriented in vitro kit, called Human HepatoPac, for identification and profiling of drug metabolites.
Automation > Laboratory Instrumentation > News
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Latest Laboratory Instrumentation News and Insight

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New Malvern Application Note Shows Value of Nanoparticle Tracking Analysis in Exosome Studies
Malvern Instruments has published a new application note that examines the use of the company’s NanoSight Nanoparticle Tracking Analysis (NTA) technology in the study of extracellular vesicles, in this case exosomes, where ensuring the stability of sample preparations is an essential precursor to more detailed research work.
Automation > Laboratory Instrumentation > Press Releases
Accelerating the Development of Optimised Therapeutic Protein Formulations Using Differential Scanning Calorimetry
Biomolecules for therapeutic use must be stabilized in their active, native forms right through to administration to the patient and delivery to their site of action. Stability screening of biopharmaceutical formulations at an early stage helps ensure that further investment is focused on those that demonstrate the best potential for further drug development. Differential scanning calorimetry (DSC) is a technique that can be used to rapidly determine optimum solution conditions for protein formulation stability, helping to identify the best formulation candidates and accelerate development. This application note describes Malvern MicroCal DSC technology and its use in formulation development.
Automation > Laboratory Instrumentation > Case Studies
Assessing Drug Encapsulation Efficiency Using Nanoparticle Tracking Analysis
Here we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
Automation > Laboratory Instrumentation > Case Studies
GPC Characterisation of Nylon using Formic Acid for Reduced Cost per Analysis
Gel permeation chromatography (GPC) or, equivalently, size-exclusion chromatography (SEC) is a widely used technique to characterise a wide variety of macromolecules, including, but not limited to commodity or bulk manufactured polymers. This technique can be used to measure the molecular weight moments, molecular weight distribution, the intrinsic viscosity, and/or hydrodynamic size of these acromolecules. While conditions that are both effective and practical have been determined for many of these commodity polymers (i.e. THF for polystyrene, chlorinated benzenes for polyolefins), some need further optimisation in one aspect or another. This application note describes one such polymer, nylon, where changes in operating conditions can lead to improvements in both cost and health and safety.
Automation > Laboratory Instrumentation > Case Studies
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 3. DLS Deconvolution Algorithms
| By Malvern Instruments
In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. In this third white paper of the series, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.
Automation > Laboratory Instrumentation > White Papers
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 2. Concentration Effects and Particle Interactions
| By Malvern Instruments
In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. In this second white paper of the series, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.
Automation > Laboratory Instrumentation > White Papers
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations:Principles, Measurements and Analysis - 1. Basic Principles
| By Malvern Instruments
This four-part white paper series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimise the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. Here, in Part One of this series, we provide an overview of the key principles of DLS: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform.
Automation > Laboratory Instrumentation > White Papers
Ten Reasons That the Zetasizer Nano is Chosen for Scientific Success
| By Malvern Instruments
New components and measurement techniques continue to be introduced for the Zetasizer Nano. New to the system are a Surface Zeta Potential accessory and a new diffusion barrier method for improved zeta potential measurements of protein samples. Why is the Malvern Zetasizer Nano so popular and found in a broad range of applied and fundamental scientific projects across all industries and fields? Because, it is simply the most dynamic and broad ranged instrument on the market for solving technical issues in today's research environment and it continues to evolve with new capabilities. Here are ten reasons why you should choose the Zetasizer Nano:
Automation > Laboratory Instrumentation > White Papers
Woodley Equipment Company Announces the Appointment of Monika Hrdinkova
Woodley Equipment Company is pleased to announce the appointment of Monika Hrdinkova as office administrator working for our clinical trials division at our Hopkinton office near Boston, Massachusetts, US. Monika has extensive business management, customer service and logistics experience and Monika’s appointment will further strengthen the clinical trials customer service team.
Automation > Laboratory Instrumentation > Press Releases
New Management Organisation of the Haselmeier Group
Haselmeier was able to successfully grow over the past few years, allowing the company to carve out a solid position in the market for medical devices. In keeping with this progress, the Haselmeier Group has restructured its management organisation to ensure this forward momentum continues successfully. The company has introduced a group executive board tasked with coordination and decision-making for all Haselmeier locations. The group executive board will ensure consistent, effective management of the Haselmeier sites, thereby coordinating the group's strategy.
Automation > Laboratory Instrumentation > Press Releases
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