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Laboratory Instrumentation

Cepheid, pharma firms collaborate on diagnostic test for multidrug-resistant bacterial infections By PBR Staff Writer
Cepheid has entered into a new collaboration with AstraZeneca, Cubist and GSK to encourage transformational change in infectious disease therapy.
Automation > Laboratory Instrumentation > News
BioLight announces start of clinical study with DiagnosTear dry eye syndrome diagnostic assay BioLight Life Sciences Investments announced that DiagnosTear has received all necessary approvals from Sheba Medical Center near Tel Aviv to begin a clinical study with its TeaRx, point-of-care Dry Eye Syndrome diagnostic assay. DiagnosTear is part of BioLight’s XLVision Sciences ophthalmology cluster.
Automation > Laboratory Instrumentation > News Hepregen launches first application-oriented in vitro kit By PBR Staff Writer
Bioengineered micro-liver platforms developer Hepregen has launched its first application-oriented in vitro kit, called Human HepatoPac, for identification and profiling of drug metabolites.
Automation > Laboratory Instrumentation > News
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Latest Laboratory Instrumentation News and Insight

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Differentiation and Characterisation of Subvisible Particulates in Therapeutic Protein Products
| By Malvern Instruments
The formation of protein aggregates is a particular concern for parenteral administration biopharmaceuticals due to the potential for increased immunogenicity. As a consequence, there is an expectation from regulatory agencies for companies to monitor and, if required, reduce the levels of sub-visible particles present in therapeutic protein from manufacture through their complete shelf life.
Automation > Laboratory Instrumentation > White Papers
Revealing Kinase Inhibitor Mechanisms: ITC Leads the Way
| By Malvern Instruments
The kinome of an organism is the set of protein kinases in its genome and these protein-modifying enzymes are potential targets in a number of therapeutic areas. Studies to characterise the human kinome, together with the explosion of available kinase crystal structures over recent years, have led to an increased focus on kinases as potential targets for pharmaceutical intervention.
Automation > Laboratory Instrumentation > White Papers
Ten Ways to…Optimise Rheology to Increase Dispersion/Colloidal/Emulsion Stability
| By Malvern Instruments
The following ten points highlight general methods of designing and interpreting rheological tests to optimise sample stability.
Automation > Laboratory Instrumentation > White Papers
Identification of Agglomerates Using Automated Image Analysis
| By Malvern Instruments
The identification of agglomerates is seen as a challenge across many different industries. Automated image analysis systems provide a means for the classification of agglomerates, by differentiating particles based on their morphological parameters. The inclusion of spectroscopic measurements alongside imaging (MDRS) aids in understanding the type of agglomeration occurring with the sample.
Automation > Laboratory Instrumentation > White Papers
New Accessories for the Mastersizer 3000 Support Smarter Pharmaceutical Particle Size Analysis
New 'third anniversary' accessories for the Mastersizer 3000 from Malvern Instruments reduce the time and cost of developing and validating robust methods for pharmaceutical particle size analysis. Correlations between particle size and bioavailability make particle size analysis a critical activity for the pharmaceutical industry.
Automation > Laboratory Instrumentation > Press Releases
SSB’s Production Facility Design for WuXi AppTec Receives Honorable Mention at the ISPE Facility of the Year Awards 2014
The WuXi AppTec bulk cell culture production facility designed by Sartorius Stedim Biotech (SSB), a leading international supplier of pharmaceutical and biotech equipment, received an honorable mention in the 2014 Facility of the Year Awards. The awards were presented by the International Society for Pharmaceutical Engineering (ISPE) at its Annual Meeting in Las Vegas last week.
Automation > Laboratory Instrumentation > Press Releases
Ensuring Accurate and Repeatable Measurement of Proteins Using the Zetasizer APS
| By Malvern Instruments
In this application note, well known protein samples were used in a crosscontamination test to investigate the accuracy and repeatability of the Zetasizer APS dynamic light scattering (DLS) system.
Automation > Laboratory Instrumentation > White Papers
Effect of Excipients on Protein Formulation Viscosity
| By Malvern Instruments
In the development of injectable biotherapeutics, drug efficacy and patient experience are both very important parameters. In order to maximize activity and efficacy, biotherapeutics are usually delivered intravenously or subcutaneously in high concentrations, typically >100g/mL, due to their short half-life in plasma.
Automation > Laboratory Instrumentation > White Papers
Reverse Engineering of a Pharmaceutical Formulation Using the Morphologi G3-ID
| By Malvern Instruments
According to the definition established by the FDA, a generic drug is "a drug product which is comparable to a reference listed drug (RLD) product in dosage form, strength, route of administration, quality, performance characteristics, and intended use". Rigorous rules and regulations pertaining to abbreviated new drug application (ANDA) submissions are complex and the generic drug industry strives to meet these regulations to obtain FDA's approval.
Automation > Laboratory Instrumentation > White Papers
Molecular Weight Measurements of an Antibody Using Viscotek SEC-MALS 20
| By Malvern Instruments
Therapeutic recombinant antibodies, primarily of the Immunoglobulin G isotype (IgG), represent a growing proportion of biopharmaceuticals. There are an ever increasing number of approved antibody therapies available to treat a variety of modern-day diseases such as cancer, rheumatoid arthritis and diabetes. With many more candidate IgG's in the biopharmaceutical development pipeline the pressure to accurately understand and develop these candidates becomes more and more important.
Automation > Laboratory Instrumentation > White Papers
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