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Laboratory Instrumentation

Cepheid, pharma firms collaborate on diagnostic test for multidrug-resistant bacterial infections By PBR Staff Writer
Cepheid has entered into a new collaboration with AstraZeneca, Cubist and GSK to encourage transformational change in infectious disease therapy.
Automation > Laboratory Instrumentation > News
BioLight announces start of clinical study with DiagnosTear dry eye syndrome diagnostic assay BioLight Life Sciences Investments announced that DiagnosTear has received all necessary approvals from Sheba Medical Center near Tel Aviv to begin a clinical study with its TeaRx, point-of-care Dry Eye Syndrome diagnostic assay. DiagnosTear is part of BioLight’s XLVision Sciences ophthalmology cluster.
Automation > Laboratory Instrumentation > News Hepregen launches first application-oriented in vitro kit By PBR Staff Writer
Bioengineered micro-liver platforms developer Hepregen has launched its first application-oriented in vitro kit, called Human HepatoPac, for identification and profiling of drug metabolites.
Automation > Laboratory Instrumentation > News
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Latest Laboratory Instrumentation News and Insight

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Developing a Bioformulation Stability Profile
| By Malvern Instruments
When used in combination, light scattering and microcapillary viscometry can be used to develop a stability profile to screen biotherapeutic candidates, with light scattering providing a suite of dilute solution properties and microcapillary viscometry providing analysis of viscosity even at high sample concentration.
Automation > Laboratory Instrumentation > White Papers
Real-Time Particle Sizing for Granulation Control
| By Malvern Instruments
This paper considers various granulation processes and the use of real-time particle size measurement in their optimisation, focusing on two different sizing methods: laser diffraction and the spatial filter technique (SFT).
Automation > Laboratory Instrumentation > White Papers
Laser Diffraction and Automated Imaging: Complementary Techniques for Nasal Spray Development
| By Malvern Instruments
Nasal spray products are increasingly valued for delivering systemic as well as locallyacting therapies, most notably hormone and migraine treatments. The large surface area and rich blood supply of the nasal passages aid the rapid absorption of drug entities, with their close proximity to the central nervous system being of particular benefit.
Automation > Laboratory Instrumentation > White Papers
Automation of QC Microscope Measurements of a Pharmaceutical Ointment Using the Morphologi Particle Characterisation System
| By Malvern Instruments
In Quality Control (QC) procedures many pharmaceutical companies rely on microscope-based analyses to identify, qualify and or quantify solid particles meeting specified size criteria.
Automation > Laboratory Instrumentation > White Papers
Applications of Isothermal Titration Calorimetry and Differential Scanning Calorimetry in Biopharmaceutical
| By Malvern Instruments
Development of protein-based therapeutics is a challenging task due to inherent protein instabilities, which can manifest as physical instability (unfolding, aggregation, adsorption), and chemical degradation (oxidation, deamidation, cleavage). Such instabilities can lead to reduced activity of the protein or even generation of potentially immunogenic species.
Automation > Laboratory Instrumentation > White Papers
Evaluating Product Delivery Characteristics from a Bottle, Tube or Spray Pack
| By Malvern Instruments
Many consumer products are packaged in tubes or bottles where product application involves pumping the product through a nozzle. Such products tend to be shearthinning products where the viscosity drops during the extrusion process due to the increasing shear rate, and then recovers on exiting the nozzle as the shear rate is reduced.
Automation > Laboratory Instrumentation > White Papers
Differential Scanning Calorimetry as a Tool for Rapid and Efficient Development of Economical Biopharmaceutical Processes
| By Malvern Instruments
Biopharmaceutical process development can be costly and time-consuming. The ultimate goal is to maximise the yield of purified product by the most costeffective, reproducible and robust route.
Automation > Laboratory Instrumentation > White Papers
Using Differential Scanning Calorimetry to Accelerate Liquid Formulation Development for Protein Biopharmaceuticals
| By Malvern Instruments
Monoclonal antibody development projects exist for a wide variety clinical indications. Recombinant proteins of commercial interest, including monoclonal antibodies, need additional properties beyond their biological activity to enable their development into successful biopharmaceuticals.
Automation > Laboratory Instrumentation > White Papers
Enhanced Aggregate Detection: Monitoring
| By Malvern Instruments
The high sensitivity of dynamic light scattering (DLS) to protein aggregation explains the wide use of Zetasizer instruments within the biopharmaceutical industry. Since the amount of light scattered by a particle is proportional to size, trace amounts of aggregate can be detected and sized using DLS.
Automation > Laboratory Instrumentation > White Papers
MicroCal ITC Range - Determine the Binding Parameters of Biomolecules in a Single Analysis
MicroCal ITC isothermal titration calorimeters are used to study a wide range of biomolecular interactions. The applications range from drug design to fundamental research such as the understanding and regulation of signal transduction pathways.
Automation > Laboratory Instrumentation > Products
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