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Laboratory Instrumentation

Cepheid, pharma firms collaborate on diagnostic test for multidrug-resistant bacterial infections By PBR Staff Writer
Cepheid has entered into a new collaboration with AstraZeneca, Cubist and GSK to encourage transformational change in infectious disease therapy.
Automation > Laboratory Instrumentation > News
BioLight announces start of clinical study with DiagnosTear dry eye syndrome diagnostic assay BioLight Life Sciences Investments announced that DiagnosTear has received all necessary approvals from Sheba Medical Center near Tel Aviv to begin a clinical study with its TeaRx, point-of-care Dry Eye Syndrome diagnostic assay. DiagnosTear is part of BioLight’s XLVision Sciences ophthalmology cluster.
Automation > Laboratory Instrumentation > News Hepregen launches first application-oriented in vitro kit By PBR Staff Writer
Bioengineered micro-liver platforms developer Hepregen has launched its first application-oriented in vitro kit, called Human HepatoPac, for identification and profiling of drug metabolites.
Automation > Laboratory Instrumentation > News
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Latest Laboratory Instrumentation News and Insight

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Accelerating Deformulation: A New Whitepaper from Malvern Instruments for Generic Tablet Development
A new whitepaper from Malvern Instruments on Oral Solid Dose (OSD) deformulation demonstrates how the analytical technique of Morphologically Directed Raman Spectroscopy (MDRS) can be used to accelerate the development of generic products to a successful conclusion.
Automation > Laboratory Instrumentation > Press Releases
FT-MIR Routine Spectrometer
Bruker's FT-MIR routine spectrometers are compact, low-cost and are ideal for high-throughput screening.
Automation > Laboratory Instrumentation > Products
Malvern Zetasizer APS Delivers Unattended Protein Screening for Medicon Valley’s SARomics Biostructures
An automated dynamic light scattering system from Malvern Instruments has become established as an essential part of the analytical toolkit used by SARomics Biostructures AB, a leading provider of protein 3D structure determination and structure-based drug design services. The Zetasizer APS automated plate sampling system is supporting the systematic study of the aggregation behavior of proteins, a fundamental component of the services provided by SARomics Biostructures. The company, which is based in Lund, Sweden within the biotech cluster of the Medicon Valley, is a research-intensive organisation with clients around the world.
Automation > Laboratory Instrumentation > Press Releases
New Malvern Application Note Shows Value of Nanoparticle Tracking Analysis in Exosome Studies
Malvern Instruments has published a new application note that examines the use of the company’s NanoSight Nanoparticle Tracking Analysis (NTA) technology in the study of extracellular vesicles, in this case exosomes, where ensuring the stability of sample preparations is an essential precursor to more detailed research work.
Automation > Laboratory Instrumentation > Press Releases
Accelerating the Development of Optimised Therapeutic Protein Formulations Using Differential Scanning Calorimetry
Biomolecules for therapeutic use must be stabilized in their active, native forms right through to administration to the patient and delivery to their site of action. Stability screening of biopharmaceutical formulations at an early stage helps ensure that further investment is focused on those that demonstrate the best potential for further drug development. Differential scanning calorimetry (DSC) is a technique that can be used to rapidly determine optimum solution conditions for protein formulation stability, helping to identify the best formulation candidates and accelerate development. This application note describes Malvern MicroCal DSC technology and its use in formulation development.
Automation > Laboratory Instrumentation > Case Studies
Assessing Drug Encapsulation Efficiency Using Nanoparticle Tracking Analysis
Here we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
Automation > Laboratory Instrumentation > Case Studies
GPC Characterisation of Nylon using Formic Acid for Reduced Cost per Analysis
Gel permeation chromatography (GPC) or, equivalently, size-exclusion chromatography (SEC) is a widely used technique to characterise a wide variety of macromolecules, including, but not limited to commodity or bulk manufactured polymers. This technique can be used to measure the molecular weight moments, molecular weight distribution, the intrinsic viscosity, and/or hydrodynamic size of these acromolecules. While conditions that are both effective and practical have been determined for many of these commodity polymers (i.e. THF for polystyrene, chlorinated benzenes for polyolefins), some need further optimisation in one aspect or another. This application note describes one such polymer, nylon, where changes in operating conditions can lead to improvements in both cost and health and safety.
Automation > Laboratory Instrumentation > Case Studies
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 3. DLS Deconvolution Algorithms
| By Malvern Instruments
In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. In this third white paper of the series, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.
Automation > Laboratory Instrumentation > White Papers
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 2. Concentration Effects and Particle Interactions
| By Malvern Instruments
In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. In this second white paper of the series, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.
Automation > Laboratory Instrumentation > White Papers
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